Current in vivo Assays for Cutaneous Toxicity: Local and Systemic Toxicity Testing

Toxicity Testing and the Toxicity Testing and the Current Situation in IRAN

Toxicity Testing and the Toxicity Testing and the Current Situation in IRAN

Local Anesthetics Systemic Toxicity.

Lidocaine Hydrochloride is an amide ester, which is widely used local anesthetic agent that is well tolerated but what is less known is the occurrence of systemic toxicity which manifests in the central nervous and cardiovascular systems. We report here 3 cases of Lidocaine associated Seizures.

Local Anesthetic Systemic Toxicity.

Local anesthetics are commonly used in the perioperative environment to facilitate surgical procedures or to provide postoperative pain management for patients. The use of local anesthetics, however, introduces the risk of complications resulting from local anesthetic systemic toxicity and the risks of increased morbidity and mortality for the surgical patient. Systemic toxicity from the inject...

Local anesthetic systemic toxicity.

Local anesthetic systemic toxicity (LAST) is a rare yet devastating complication from the administration of local anesthesia. The ability to recognize and treat LAST is critical for clinicians who administer these drugs. The authors reviewed the literature on the mechanism, treatment, and prevention of LAST, with the goal of proposing a practical method for its management.